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KMID : 1200020110350060602
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Diabetes & Metabolism Journal
2011 Volume.35 No. 6 p.602 ~ p.609
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Serum Cystatin C Reflects the Progress of Albuminuria
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Yoo Jeong-Seon
Lee Young-Mi
Lee Eun-Hae
Kim Ji-Woon
Lee Shin-Young
Jeong Ki-Cheon
Kang Shin-Ae
Park Jong-Suk
Nam Joo-Young
Ahn Chul-Woo
Song Young-Duk
Kim Kyung-Rae
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Abstract
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Background: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.
Methods: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.
Results: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.
Conclusion: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
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KEYWORD
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Albuminuria, Cystatin C, Creatinine, Diabetes mellitus, type 2, Diabetic nephropathies
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